漆永梅-凯发k8官方网娱乐官方

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  • 职  称: 副教授/硕士研究生导师
  • 所在部门: 动物学研究所
  •  办公室: 天演楼439
  • 联系电话:
  • 传真号码:
  • 电子邮件: [email protected]
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学习经历

2005/09-2011/07,兰州大学,生命科学学院,硕博连读/博士,导师:张迎梅教授

2008/09-2010/07,美国马里兰大学帕克分校(university of maryland, college park),“国家建设高水平大学公派研究生项目”联合培养博士研究生

2001/09-2005/07,河南师范大学,生命科学学院,本科/学士

工作经历

2016.05-今,兰州大学,生命科学学院,副教授

2011/07-2016.04,兰州大学,生命科学学院,讲师

2008/07-2011/06,兰州大学联合培养研究生师资

 
社会工作
研究方向

目前主要从事线粒体自噬和线粒体动态的分子机制研究:

1.以哺乳动物细胞和小鼠为模型研究线粒体自噬和线粒体动态的影响因素及分子机制;

2.以哺乳动物细胞和小鼠为模型探讨线粒体稳态与癌症发生发展、神经退行性疾病的关系及相关分子机制;

3.以斑马鱼为模型探究环境污染物对其神经系统和免疫系统的影响,并从线粒体稳态维持的角度探讨其分子机制。

 

项目成果

1.主持甘肃省自然科学基金项目,20jr5ra250,nix介导的线粒体自噬在镉致小鼠肾脏毒性中的作用机制研究

2.主持甘肃省外科肿瘤分子诊断与精准治疗重点实验室开放基金,2019gszdsys03,nix介导的线粒体自噬在亚精胺致胃癌细胞死亡中的作用及其机制研究

3.主持国家自然科学基金青年项目,31300941,ros和atm蛋白在亚精胺致线粒体自噬过程中的调控机理研究

4.主持甘肃省自然科学基金项目,145rjza120,铅对小鼠肾脏线粒体自噬的影响及机制研究

 

荣誉、获奖

2021年,指导本科生完成大学生生命科学竞赛项目(2021,科学探究类)“大黄素诱导的线粒体自噬对宫颈癌细胞侵袭、转移的影响及作用机制研究”,分获甘肃省和全国一等奖。

教学及指导研究生情况

承担本科生《生物化学》和《生物化学实验》课程教学

承担研究生《环境生物监测-动物学专题》和《动物毒理学》课程教学

发表论文及专著

代表性论文* 通讯作者

     1. xingjie zhang, lin ma, yue tang, jiangyuan han, yongmei qi*, dejun huang*. low-dose cadmium exposure facilitates cell proliferation by promoter hypermethylation of rassf1a and dapk1 genes. environmental toxicology. 2021, 36(11):2313-2321.

2. yihong tian, yongmei qi*, sajid naeem, ke gao, yingmei zhang*. spermidine-induced autophagy regulates the survival of hela cells. pakistan journal of zoology, 2021, 53(1):239-244.

3. yongmei qi#, lin ma#1, sajid naeem, xueyan gu2, xijuan chao, cong yuan, dejun huang*. pb induced mitochondrial fission of fibroblast cells via atm activation. journal of hazardous materials, 2021, 416: 126177.

4. yan hu1, dong li1, xuan ma, rongjian liu, yongmei qi, cong yuan, dejun huang*. effects of 2,4-dichlorophenol exposure on zebrafish: implications for the sex hormone synthesis. aquatic toxicology, 2021, 236: 105868.

5. ke gao, chengfei zhang, yihong tian, sajid naeem, yingmei zhang, yongmei qi*. the role of endoplasmic reticulum stress in lead (pb)-induced mitophagy of hek293 cells. toxicology and industrial health, 2020, 36(12): 1002-1009.

6. xijuan chao*, yongmei qi, yingmei zhang*.highly photostable fluorescent tracker with ph-insensitivity for long-term imaging of lysosomal dynamics in live cells. acs sensors, 2020.

7.sajid naeem, yongmei qi*, yihong tian, yingmei zhang*. nix compensates lost role of parkin in cd-induced mitophagy in hela cells through phosphorylation. toxicology letters, 2020, 326:1-10.

8. chen zhang, dong li, tingting ge, jiangyuan han, yongmei qi*, dejun huang*. 2,4-dichlorophenol induces feminization of zebrafish (danio rerio) via dna methylation. science of the total environment. 2020, 708:135084.  

9.cong yuan, chen zhang, yongmei qi, dong li, yan hu, dejun huang*, 2.2,4-dichlorophenol induced feminization of zebrafish by down-regulating male-related genes through dna methylation. ecotoxicology and environmental safety. 2019 dec ;189:110042. doi: 10.1016/j.ecoenv.2019.110042 

10. xueyan gu, yongmei qi*,zengxiu feng,lin ma, ke gao,yingmei zhang*, lead (pb) induced atm-dependent mitophagy via pink1/parkin pathway. toxicology letters, 2018, 291:92-100. 

11. yongmei qi#, qian qiu#, xueyan gu, yihong tian, yingmei zhang*, atm mediates spermidine-induced mitophagy via pink1 and parkin regulation in human fibroblasts, scientific reports, 2016, 6, 24700. 

12. yongmei qi, yingmei zhang*, yingxia liu, wenya zhang, nonylphenol decreases viability and arrests cell cycle via reactive oxygen species in raji cells, experimental and toxicologic pathology, 2013, 65 (1-2): 69-72.

13. yongmei qi, ailing li, dejun huang, yihong tian, yingmei zhang*, exogenous s-adenosyl-l-methionine could inhibit c-myc overexpression induced by as2o3 in normal human liver hl-7702 cells, journal of health science, 2011, 57(2): 188-191.

14. yongmei qi, norberta w schoene, frederick m lartey, wen-hsing cheng*, selenium compounds activate atm-dependent dna damage response via the mismatch repair protein hmlh1 in colorectal cancer cells, the journal of biological chemistry, 2010, 285(43): 33010–33017.

15. dejun huang*, xiaoning zhang, chen zhang, hui li, dong li, yan hu, feng yang, yongmei qi. 2018. 2,4-dichlorophenol induces dna damage through ros accumulation and gsh depletion in goldfish carassius auratus. environ mol mutagen. 59, 798-804. 

16. tingting ge, jiangyuan han, yongmei qi, xueyan gu, lin ma, chen zhang, sajid naeem, dejun huang*. 2017. the toxic effects of chlorophenols and associated mechanisms in fish. aquatic toxicology. 184, 78-93. 

17. xue wei, yongmei qi, xiaoning zhang, xueyan gu, hui cai, jing yang, yingmei zhang*, ros act as an upstream signal to mediate cadmium-induced mitophagy in mouse brain, neurotoxicology, 2015, 46:19-24.

18. xue wei, yongmei qi, xiaoning zhang, qian qiu, xueyan gu, chen tao, dejun huang, yingmei zhang*, cadmium induces mitophagy through ros-mediated pink1/parkin pathway, toxicology mechanisms and methods, 2014, 24(7):504-511.

19. zhen an, yongmei qi, dejun huang, xueyan gu, yihong tian, ping li, hui li, yingmei zhang*, egcg inhibits cd2 -induced apoptosis through scavenging ros rather than chelating cd2  in hl-7702 cells, toxicology mechanisms and methods, 2014, 24(4): 259-267.

20. xiaoning zhang, xiaona zhang, yongmei qi, dejun huang*, yingmei zhang*,  2,4-dichlorophenol induces er stress-mediated apoptosis via eif2a dephosphorylation in vitroenvironmental toxicology, 2016, 31(2): 245-255.

21. weiwei li, xueyan gu, xiaoning zhang, jinxin kong, nan ding, yongmei qi, yingmei zhang, jufang wang, dejun huang*, cadmium delays non-homologous end joining (nhej) repair viainhibition of dna-pkcs phosphorylation and downregulation ofxrcc4 and ligase iv, mutation research/fundamental and molecular mechanisms of mutagenesis, 2015, 779: 112-123. 

22. xiaoning zhang, xiaona zhang, zhidan niu, yongmei qi, dejun huang*, yingmei zhang*, 2,4,6-trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis, international journal of toxicology, 2014, 33(6): 532-541.

23. xiaoning zhang, hui li, qian qiu, yongmei qi, dejun huang*, yingmei zhang*, 2,4-dichlorophenol induces global dna hypermethylation through the increase of s-adenosylmethionine and the upregulation of dnmts mrna in the liver of goldfish carassius auratuscomparative biochemistry and physiology - part c: toxicology & pharmacology, 2013, 160c: 54-59.

24. hui li, xiaoning zhang, qian qiu, zhen an, yongmei qi, dejun huang*, yingmei zhang*, 2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (ctenopharyngodon idella) through mitochondrial pathway, aquatic toxicology, 2013, 140-141: 117-122.

25. peng chen, yingxia liu, yanqing sun, che chen, yongmei qi, yingmei zhang*, azt and emodin exhibit synergistic growth-inhibitory effects on k562/adm cells by inducing s phase cell cycle arrest and suppressing mdr1 mrna/p-gp protein expression, pharmacology biology, 2013, 51(12):1586-1591.

 

 

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