yi wu-凯发k8官方网娱乐官方


  • title: 教授、博士生导师
  • department: 生物物理学研究所
  • address:
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  • email: [email protected]
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academic appointments




administrative appointments
■ 中国生物物理学会理事,2006-;

■ 中国电子显微镜学会理事,2008-;

■ 生物物理学报副主编,2010-;

■ biophysics reports副主编,2015-。


honors & awards
■ 清华大学优秀博士学位论文一等奖,2003;
■ 教育部新世纪优秀人才支持计划,2005;
■ 国家自然科学二等奖(3/5),2005;
■ 第四届亚太血栓与止血大会青年研究奖,2006;
■ 第六届甘肃青年科技奖,2007;
■ 第十三届甘肃五四青年奖章标兵,2009;

■ 第一届贝时璋青年生物物理学家奖,2009;

■ 第十二届霍英东青年教师基金,2010;

■ 国家自然科学基金优秀青年基金,2012。


■ 国家自然科学基金重点项目1项,面上项目13项;
■ 国家自然科学基金优秀青年科学基金1
■ 国家自然科学基金国际合作项目2项;
■ 霍英东青年教师基金1项;
■ 教育部新世纪优秀人才支持计划2项;
■ 教育部博士点基金3项;
■ 教育部科技研究重点项目1

■ fei合作研究基金1项;

■ 中央高校基本科研业务费重点项目1项;

■ 兰州大学人才引进专项2




[1] zhang s.-c., wang m.-y., feng j.-r., chang y., ji s.-r. *, wu y.* (2020) reversible promoter methylation determines fluctuating expression of acute phase proteins. elife, 9: e51317. (if 7.551)

[2] li h.-y., liu x.-l., liu y.-t., jia z.-k., filep j.g., potempa l.a., ji s.-r. *, wu y.* (2019) matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of c-reactive protein. cardiovascular research, 115(2): 440-452. (if 7.014)

[3] zhang l., li h.-y., li w., shen z.-y., wang y.-d., ji s.-r. *, wu y.* (2018) an elisa assay for quantifying monomeric c-reactive protein in plasma. frontiers in immunology, 9: 511. (if 5.511)

[4] jia z.-k., li h.-y., liang y.-l., potempa l.a., ji s.-r.*, wu y.* (2018) monomeric c-reactive protein binds and neutralizes rankl-induced osteoclast differentiation. frontiers in immunology, 9: 234. (if 5.51)

[5] lv j.-m., lv s.-q., liu z.-p., zhang j., gao b.-x., yao z.-y., wu y.-x., potempa l.a., ji s.-r.*, long m.*, wu y.* (2018) conformational folding and disulfide bonding drive distinct stages of protein structure formation. scientific reports, 8: 1494. (if 4.122)

[6] li q.-y., li h.-y., fu g., yu f.*, wu y.*, zhao m.-h. (2017)  autoantibodies against c-reactive protein influences complement activation and clinical course in lupus nephritisjournal of the american society of nephrology28 (10): 3044-3054. (if 8.655)

[7] li h.-y., wang j., meng f., jia z.-k., su y., bai q.-f., lv l.-l., ma f.-r., potempa l.a., ji s.-r.*, wu y.* (2016) an intrinsically disordered motif mediates diverse actions of monomeric c-reactive protein. journal of biological chemistry, 291 (16): 8795-8804. (if 4.01)

[8] ouyang y., zhu l.*, li y.-f., guo m.-m., liu y., cheng j., zhao j., wu y.* (2016) architectural plasticity of ampk revealed by electron microscopy and x-ray crystallography. scientific reports, 6:24191. (if 4.122)

[9] zhang l., liu s.-h., wright t.t., shen z.-y., li h.-y., zhu w., potempa l.a., ji s.-r.*, szalai a.j.*, wu y.* (2015) c-reactive protein directly suppresses t helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. journal of immunology, 194 (11): 5243-5252. (if 4.539)

[10] li h.-y., wang j., wu y.-x., zhang l., liu z.-p., filep j.g., potempa l.a., wu y.*, ji s.-r.* (2014) topological localization of monomeric c-reactive protein determines pro-inflammatory endothelial cell responses. journal of biological chemistry, 289 (20): 14283-14290. (if 4.01)

[11] wang m.-y., zhou h.-h., zhang s.-c., hui f., zhu w., su h.-x., guo h.-y., li x.-w., ji s.-r.*, wu y.* (2014) recurrent mutations at c-reactive protein promoter snp position -286 in human cancers. cell research, 24(4): 505-508. (if 15.393)

[12] zhang y.-j., shi j.-m., bai c.-j., wang h., li h.-y., wu y.*, ji s.-r.* (2012) intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. journal of biological chemistry, 287(1): 748-756. (if 4.01)

[13] el kebir d., zhang y., potempa l.a., wu y., fournier a., filep j.g.* (2011) c-reactive protein-derived peptide 201–206 inhibits neutrophil adhesion to endothelial cells and platelets through cd32. journal of leukocyte biology, 90(6): 1167-1175. (if 4.224)

[14] wang m.-y., ji s.-r., bai c.-j., el kebir d., li h.-y., shi j.-m., zhu w., costantino s., zhou h.-h., potempa l.a., zhao j., filep j.g.*, wu y.* (2011) a redox switch in c-reactive protein modulates activation of endothelial cells. faseb journal, 25(9): 3186-3196. (if 5.595)

[15] zhu l., chen l., zhou x.-m., zhang y.-y., zhang y.-j., zhao j., ji s.-r., wu j.-w.*, wu y.* (2011) structural insights into the architecture and allostery of full-length amp-activated protein kinase. structure, 19(4): 515-522. (if 4.907)

[16] wang b.-b., yu c.-h., xi y.-b., cai h.-c., wang j., zhou s.-r., zhou s.-y., wu y., yan y.-b.*, ma x.*, xie l.-x.* (2011) a novel crygd mutation (p.trp43arg) causing autosomal dominant congenital cataract in a chinese family. human mutation, 32(1): e1939-e1947. (if 5.359)

[17] liu r.-q., zhou q.-h., ji s.-r., zhou q., feng d., wu y., sui s.-f.* (2010) membrane localization of β-amyloid 1–42 in lysosomes: a possible mechanism for lysosome labilization. journal of biological chemistry, 285(26): 19986-19996. (if 4.01)

[18] ji s.-r., ma l., bai c.-j., shi j.-m., li h.-y., filep j.g., potempa l.a., zhao j., wu y.* (2009) monomeric c-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. faseb journal, 23(6): 1806-1816. (if 5.595)

[19] shen q.t., bai x.c., chang l.f., wu y., wang h.w., sui s.-f.* (2009) bowl-shaped oligomeric structures on membranes as degp’s new functional forms in protein quality control. proceedings of the national academy of sciences of the united states of america, 106(12): 4858-4863. (if 9.504)

[20] jiang j., zhang x., chen y., wu y., zhou z.h., chang z., sui s.-f.* (2008) activation of degp chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. proceedings of the national academy of sciences of the united states of america, 105(33): 11939-11944. (if 9.504)

[21] ji s.-r., wu y.*, zhu l., potempa l.a., sheng f.-l., lu w., zhao j. (2007) cell membranes and liposomes dissociate c-reactive protein (crp) to form a new, biologically active structural intermediate: mcrpm. faseb journal, 21(1): 284-294. (if 5.595)

[22] ji s.-r., wu y.*, potempa l.a., liang y.-h., zhao j. (2006) effect of modified c-reactive protein on complement activation: a possible complement regulatory role of mcrp in atherosclerotic lesions. arteriosclerosis, thrombosis, and vascular biology, 26(4): 935-941. (if 6.086)

[23] ji s.-r., wu y.*, potempa l.a., qiu q., zhao j. (2006) interactions of c-reactive protein with low density lipoproteins: implications of an active role of modified c-reactive protein in atherosclerosis. international journal of biochemistry & cell biology, 384(4): 648-661. (if 3.247)

[24] wu y., he y., bai j., ji s.-r., tucker w.c., chapman e.r.*, sui s.-f.* (2003) visualization of synaptotagmin i oligomers assembled on lipid monolayers. proceedings of the national academy of sciences of the united states of america, 100(4): 2082-2087. (if 9.504)

[25] ji s.-r., wu y., sui s.-f.* (2002) cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (abeta 1-40), which may potentially inhibit the fibril formation. journal of biological chemistry, 277(8): 6273-6279. (if 4.01)

[26] wu y., wang h.-w., ji s.-r., sui s.-f.* (2003) two-dimensional crystallization of rabbit c-reactive protein monomeric subunits. acta crystallographica section d-biological crystallography59(5): 922-926. (if 3.099)



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